CALLUS CULTURE AS THE METHOD IN PROVIDING ANTIMALARIAL COMPOUNDS OF PIPER GENUS

Malaria is still a serious cases all over the world especially in tropical country with predict number 300-500 millions people infected per year. The resistence of these anti-malaria substance make new effort to find strategy against malaria. This study aim summarize potential Piper genus as source antimalarial compound and recent research callus induction piper plant obtain metabolites.The represent 11 species were chemically studied assayed plasmodium. isolates from several 20,60-Dihydroxy-40-methoxydihydro-chalcone,3-Farnesyl-p-hydroxybenzoic acid, Piperine, Chabamide, Benzoic acid derivatives, Guineensine, pellitorine, rachystamide B, sarmentine, sermentosine, 5,8-Hydroxy-7-methoxyflavone, Prenylated hydroxybenzoic 4-Nerolidylcatechol, Piperitone, Champor, Viridiflorol (EO). An propagate necessary antiplasmodial resources by has been conducted for 7 such betle, P. colubrinumm, crocatum, longum, nigrum, permucronatum solmsianum higher content secondary metabolites different growth hormone (PGR) supplementation while there are most have not well studied. It conclude that culture could be promising method antimalarial.